Abstract Background Exercise during postnatal development plays a key role in determining adult bone mass and reducing the risk of fracture and osteoporosis later in life.However, the relationship between mechanically-induced osteogenesis and age is unclear.Elevated levels of estrogen during puberty may inhibit periosteal bone formation.Thus, magnitudes of mechanically-induced osteogenesis may be vary with pubertal state.
Methods The present study uses a murine model to examine age-related changes in bone formation at the femoral midshaft with voluntary exercise.Pre- dosatron d40mz2 to peripubertal mice aged 3 weeks and peri- to postpubertal mice aged 7 weeks were randomly divided into sedentary and exercised groups and subjected to histomorphometric comparison after 4 weeks of treatment.Results Results of the experiment indicate that exercise significantly increased freetress deep twist crochet hair 14 inch osteogenesis on the periosteal and endocortical surface of the mice in the older age group (P P Conclusion These findings suggest that the amount and location of mechanically-induced osteogenesis differs by age during skeletal development.Late adolescence may be the optimal time to accrue bone mass and maximize bone strength.